UNC Blood Research Center https://www.med.unc.edu/bloodresearchcenter/ Tue, 20 Jan 2026 19:08:14 +0000 en-US hourly 1 Key Lab publishes study describing rapid and sensitive assay for hyperfibrinolysis in plasma https://www.med.unc.edu/bloodresearchcenter/2026/01/key-lab-publishes-study-describing-rapid-and-sensitive-assay-for-hyperfibrinolysis-in-plasma/ Fri, 02 Jan 2026 14:20:47 +0000 https://www.med.unc.edu/bloodresearchcenter/?p=6952 Key Lab publishes study describing rapid and sensitive assay for hyperfibrinolysis in plasma. In collaboration with colleagues in the UK who first described a form of severe post-partum hemorrhage (PPH) characterized by marked hyperfibrinolysis, a novel rapid assay for fibrinolytic activation in plasma developed in the lab (the Fibrinolytic Activation Screening Test or ‘FAST’ assay) reliably distinguished Acute Obstetric … Read more

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]]> Key Lab publishes study describing rapid and sensitive assay for hyperfibrinolysis in plasma.
In collaboration with colleagues in the UK who first described a form of severe post-partum hemorrhage (PPH) characterized by marked hyperfibrinolysis, a novel rapid assay for fibrinolytic activation in plasma developed in the lab (the Fibrinolytic Activation Screening Test or ‘FAST’ assay) reliably distinguished Acute Obstetric Coagulopathy from other forms of PPH in archived plasma samples. The findings are described in an online manuscript in ‘Blood Advances’.

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]]> Robert Lee, PhD and Wolfgang Bergmeier, PhD, were part of a team studying the contribution of platelets to mast cell activation in sepsis, published in the Journal Nature Communications. https://www.med.unc.edu/bloodresearchcenter/2025/12/robert-lee-phd-and-wolfgang-bergmeier-phd-were-part-of-a-team-studying-the-contribution-of-platelets-to-mast-cell-activation-in-sepsis-published-in-the-journal-nature-communications/ Fri, 19 Dec 2025 17:56:27 +0000 https://www.med.unc.edu/bloodresearchcenter/?p=6941 Robert Lee, PhD and Wolfgang Bergmeier, PhD, were part of a team studying the contribution of platelets to mast cell activation in sepsis, published in the Journal Nature Communications.     https://pubmed.ncbi.nlm.nih.gov/41339353/    

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]]> Robert Lee, PhD and Wolfgang Bergmeier, PhD, were part of a team studying the contribution of platelets to mast cell activation in sepsis, published in the Journal Nature Communications.

 

 

https://pubmed.ncbi.nlm.nih.gov/41339353/

 

 

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]]> Aleksei Martianov, awarded the Staff Excellence Award https://www.med.unc.edu/bloodresearchcenter/2025/12/aleksei-martianov-awarded-the-staff-excellence-award/ Fri, 19 Dec 2025 17:53:06 +0000 https://www.med.unc.edu/bloodresearchcenter/?p=6939 Aleksei Martianov, postdoc in the Bergmeier lab, presented his work as an oral presentation at ASH, his presentation was featured in “Best of ASH”, and he received the inaugural ASH Richard T. Silver, MD Abstract Achievement Award for Myeloproliferative Neoplasms. In addition, Aleksei was awarded the Staff Excellence Award for a postdoctoral fellow in the … Read more

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Aleksei Martianov, postdoc in the Bergmeier lab, presented his work as an oral presentation at ASH, his presentation was featured in “Best of ASH”, and he received the inaugural ASH Richard T. Silver, MD Abstract Achievement Award for Myeloproliferative Neoplasms.

In addition, Aleksei was awarded the Staff Excellence Award for a postdoctoral fellow in the Department of Biochemistry and Biophysics at UNC.

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]]> YJ Choi received a NOA for proposal entitled, “Define and Target Genetic Regulators of Fibrinogen Synthesis to Reduce Thrombosis” https://www.med.unc.edu/bloodresearchcenter/2025/12/yj-choi-received-a-noa-for-proposal-entitled-define-and-target-genetic-regulators-of-fibrinogen-synthesis-to-reduce-thrombosis/ Fri, 19 Dec 2025 17:49:45 +0000 https://www.med.unc.edu/bloodresearchcenter/?p=6936 YJ Choi, an MD/PhD trainee in Wolberg laboratory, received a NOA for her AHA proposal entitled, “Define and Target Genetic Regulators of Fibrinogen Synthesis to Reduce Thrombosis”

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]]> YJ Choi, an MD/PhD trainee in Wolberg laboratory, received a NOA for her AHA proposal entitled, “Define and Target Genetic Regulators of Fibrinogen Synthesis to Reduce Thrombosis”

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]]> Nigel Key Co-Authors Pivotal Hemophilia Gene Therapy Study in NEJM https://www.med.unc.edu/bloodresearchcenter/2025/12/nigel-key-co-authors-pivotal-hemophilia-gene-therapy-study-in-nejm/ Fri, 12 Dec 2025 17:32:38 +0000 https://www.med.unc.edu/bloodresearchcenter/?p=6934 Nigel Key Co-Authors Pivotal Hemophilia Gene Therapy Study in NEJM   Nigel Key was a contributing author on the final analysis of the HOPE-B study results that were published online in in the New England Journal of Medicine on December 7, 2025 coincident with presentation of the data at the ASH meeting in Orlando. https://www.nejm.org/doi/full/10.1056/NEJMoa2514332?query=RP … Read more

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]]> Nigel Key Co-Authors Pivotal Hemophilia Gene Therapy Study in NEJM

 

Nigel Key was a contributing author on the final analysis of the HOPE-B study results that were published online in in the New England Journal of Medicine on December 7, 2025 coincident with presentation of the data at the ASH meeting in Orlando.

https://www.nejm.org/doi/full/10.1056/NEJMoa2514332?query=RP

 

The study recruited patients with severe hemophilia B in a phase 3, open label, international protocol. The mean FIX activity attained was 36% with levels remaining constant over 5 years. This pivotal study led to FDA licensure of the first gene therapy protocol for hemophilia

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]]> Nigel Mackman featured in: 29 Carolina faculty named ‘highly cited researchers’ https://www.med.unc.edu/bloodresearchcenter/2025/12/nigel-mackman-featured-in-29-carolina-faculty-named-highly-cited-researchers/ Thu, 04 Dec 2025 13:30:13 +0000 https://www.med.unc.edu/bloodresearchcenter/?p=6898 Nigel Mackman featured in: 29 Carolina faculty named ‘highly cited researchers’   Nigel Mackman, PhD Distinguished professor of medicine Pathology, and Pharmacology   29 Carolina faculty named ‘highly cited researchers’

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]]> Nigel Mackman featured in: 29 Carolina faculty named ‘highly cited researchers’

 

Nigel Mackman, PhD Distinguished professor of medicine Pathology, and Pharmacology

 

29 Carolina faculty named ‘highly cited researchers’

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]]> Graduate students won Abstract Achievement Awards for the upcoming ASH meeting https://www.med.unc.edu/bloodresearchcenter/2025/11/two-graduate-students-won-abstract-achievement-awards-for-the-upcoming-ash-meeting/ Tue, 18 Nov 2025 19:58:20 +0000 https://www.med.unc.edu/bloodresearchcenter/?p=6892 Graduate students in the Dr. Maria Aleman’s Lab won Abstract Achievement Awards for the upcoming ASH meeting. Kwame Forbes, PhD Candidate in Bioinformatics and Computational Biology for “Decoding the gene regulatory response to iron through multiomics.” Michael Sullivan, PhD Candidate in Pharmacology for “Intracellular iron levels alter the protein interactome of PCBP1.

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]]> Graduate students in the Dr. Maria Aleman’s Lab won Abstract Achievement Awards for the upcoming ASH meeting.
Kwame Forbes, PhD Candidate in Bioinformatics and Computational Biology for “Decoding the gene regulatory response to iron through multiomics.”

Michael Sullivan, PhD Candidate in Pharmacology for “Intracellular iron levels alter the protein interactome of PCBP1.

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]]> BRC November 2025 Newsletter https://www.med.unc.edu/bloodresearchcenter/2025/11/brc-november-2025-newsletter/ Tue, 18 Nov 2025 13:51:57 +0000 https://www.med.unc.edu/bloodresearchcenter/?p=6886 View BRC November 2025 Newsletter November 2025 Newsletter

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]]> View BRC November 2025 Newsletter

November 2025 Newsletter

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]]> Three postdoctoral fellows in the BRC have received recognition from the American Society of Hematology. https://www.med.unc.edu/bloodresearchcenter/2025/11/brc-trainees-receive-recognition-from-ash/ Thu, 13 Nov 2025 17:41:32 +0000 https://www.med.unc.edu/bloodresearchcenter/?p=6867 Dr. Aleksei Martianov (PI: Dr. Wolfgang Bergmeier) was awarded the Richard T. Silver, MD Abstract Achievement Award for Myeloproliferative Neoplasms (MPNs). He will give an oral presentation entitled “Platelet priming in MPN triggers pro-thrombotic intermediate affinity state in αIIbβ3 integrin” on Sunday December 7, 2025 at 9:30 AM in Room W304-EFGH. Dr. Nirupama Ramadas (PI: … Read more

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]]> Dr. Aleksei Martianov (PI: Dr. Wolfgang Bergmeier) was awarded the Richard T. Silver, MD Abstract Achievement Award for Myeloproliferative Neoplasms (MPNs). He will give an oral presentation entitled “Platelet priming in MPN triggers pro-thrombotic intermediate affinity state in αIIbβ3 integrin” on Sunday December 7, 2025 at 9:30 AM in Room W304-EFGH.

Dr. Nirupama Ramadas (PI: Dr. Erica Sparkenbaugh) received an ASH Abstract Achievement Award for her abstract entitled “Selective PAR1 activation mitigates pain and neuroinflammatory markers in a murine model of sickle cell disease.” Her poster session is Sunday December 7 from 6:00-8:00 PM in the Poster Hall.

Dr. Karnsasin Seanoon (PI: Drs. Brandi Reeves/Rafal Pawlinski) received an ASH Abstract Achievement Award for her abstract entitled “Thrombopoietin inhibition abrogates JAK2V617F clonal expansion in a murine model of myeloproliferative neoplasm.” Her poster session is Saturday December 6 from 5:30 – 7:30 PM in the Poster Hall.

Congratulations Dr. Martyanov, Dr. Ramadas and Dr. Seanoon!

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]]> Pathobiology and Translational Science graduate program had their annual student symposium https://www.med.unc.edu/bloodresearchcenter/2025/11/pathobiology-and-translational-science-graduate-program-had-their-annual-student-symposium/ Thu, 06 Nov 2025 16:45:18 +0000 https://www.med.unc.edu/bloodresearchcenter/?p=6852 On October 7, the Pathobiology and Translational Science graduate program had their annual student symposium. BRC trainees presented posters (YJ Choi – Wolberg Lab, Claire Reist – Flick Lab) and one gave a talk (Kylie Hutchison – Sparkenbaugh Lab). Alisa Wolberg, Steve Hur, and Erica were BRC faculty in attendance. We also had several postdocs, … Read more

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]]> On October 7, the Pathobiology and Translational Science graduate program had their annual student symposium. BRC trainees presented posters (YJ Choi – Wolberg Lab, Claire Reist – Flick Lab) and one gave a talk (Kylie Hutchison – Sparkenbaugh Lab). Alisa Wolberg, Steve Hur, and Erica were BRC faculty in attendance. We also had several postdocs, techs, and fellows come out to support the trainees

PBTS student Symposium on early October. Trainees YJ Choi, Claire Reist, Joanne Alfred and Kylie Hutchison attended.  YJ and Claire had posters and Kylie had one of three invited oral presentations. BRC faculty in attendance included Drs. Sparkenbaugh, Wolberg, Hur

 

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